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In patients taking opioids for an extended periods of time at high doses, ensure that a multimodal approach to pain management, including mental health support (if needed), is in place prior to initiating an opioid analgesic taper [see Dosage And Administration, and Warnings]

In general, if youre unable to take medications or fluids orally or need a more immediate therapeutic effect, IV therapy may be a good option

By reacting with the NO molecule, O 2 produces peroxynitrite, which interacts with the amino acid tyrosine and, through a nitration reaction, forms nitrotyrosine, an indicator of nitration levels in patients (78)

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