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Itaconate and fumarate derivatives inhibit priming and activation of the canonical NLRP3 inflammasome in macrophages

Therapeutic strategies can therefore be envisioned to increase choroidal neuroprotective functions in perinatal conditions in which choroidal detoxifying systems may be sub-optimal, or when the brain is facing adverse oxidative and chemical stresses, such as exposure to pharmacological agents or environmental toxicants, hypoxia, and hyperbilirubinemia

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Calculate your dose: Aim for 20-40mg per kg of body weight