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The gpoA transcripts, as well as tpxD and ahpD , which encode the TpxD thiol peroxidase and the AhpD alkylhydroperoxidase, respectively, were upregulated when pneumococci were exposed to H2O2
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Exposure to PTU resulted in severe thyroid hormone depletion in both serum and brain, accompanied by structural brain abnormalities, whereas PCN primarily induced hepatic enzyme activity with minimal effect on circulating thyroid hormone levels
