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In clinical trials, Retatrutide was associated with a greater increase in resting heart rate than Tirzepatide

Recent research has expanded beyond its well-known wound healing and skin regeneration properties to explore its neuroprotective potential in Alzheimer's Disease models, where it demonstrates the ability to reduce amyloid plaque formation and improve cognitive function through multiple biological pathways

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Preventing normal FOXO4 binding to p53 through FOXO4-DRI has been suggested to remove senescent cells, improve organ function, and slow biological age. The cell cycle, oxidative stress, and the insulin signaling pathways may all be affected by FOXO4-DRI, as speculated by researchers