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Chimeric Antigen Receptor (CAR T)-cell therapy currently approved by the FDA for treating B-cell acute lymphoblastic leukemia [98], B-cell lymphomas [99], and multiple myeloma [100] and is increasingly being administered to patients is associated with cytokine release syndrome (CRS)

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Additionally, a shockbubble effect may occur in brain tissue due to an acoustic impedance mismatch caused by shock waves [272], and mitochondrial dysfunction may play a crucial role [273]