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Side effects are rare but may include: Mild pain or redness at the injection site Headache Dizziness Upset stomach Reactions are highly uncommon

GLP-1 peptides (semaglutide, tirzepatide): Nausea is the most common one, especially in the early weeks when dose is being titrated up

Safety and contraindications: Who should not use tirzepatide with B12 While tirzepatide with vitamin B12 is highly effective for weight management, it is not suitable for everyone

The median relative percentage of B lymphocytes was significantly higher in both activated populations (CD86 high HLA-DR high : 17% (LC), 11% (CC) and 12% (HC)) and double-negative subsets (IgD CD27 CD24 CD38 : 5% (LC), 2% (CC) and 2% (HC)) (Extended Data Fig