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Contents: AOD9604

soft electrophiles including quinoneimines, nitrenium ions, arene oxides, quinones, imine methides and Michael acceptors will conjugate with glutathione and cysteine, whereas hard electrophiles are generally charged species like alkyl carbocations and nitrenium ions and these can be trapped with potassium cyanide 2

Berthold, C., Fraher, J., King, R

Subsequent studies of this chemically induced skin cancer model implicate inflammation and apoptosis as crucial components modulating tumor development (198), and, in many studies, GPx-1 has been shown to attenuate both inflammation and apoptosis, suggesting that these effects may contribute to tumor development in some models