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The semi-lethal concentration (LD 50 ) for Kunming mice was 382.28 mg/kg

Thirdly, low bioavailability and pre-mature degradation of curcumin resulting in sub-therapeutic levels remains the main disadvanteges of curcumin therapy that poses great challenges to date

A variety of TNF- blockers have been used for autoimmune diseases, such as rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis (229)

Even larger clinical LLMs have been developed for example, GatorTron [236] and Med-PaLM 2 [237]
