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However, recombinant proteins used were often devoid of the Fe-S cluster which is problematic because four cysteine residues now become possibly reactive and blur the conclusions
Beyond, many of the observed changes occurred in patients with BD can be considered as signs of premature aging (telomere length, oxidative stress, inflammation, disruptions on biological clocks, epigenetic aging and mitochondrial dysfunction), as prior works hypothesize that accelerated aging process is potentially implicated in the development and course of BD [52]
J Biol Chem 291: 95019512
10.1002/ACN3.553 69 HardingO.HolzerE.RileyJ
