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SIRT1 deacetylates Sterol Regulatory Element-Binding Protein-1c (SREBP-1c) and Carbohydrate Response Element-Binding Protein (ChREBP), suppressing the expression of their downstream lipogenic genes fatty acid synthase (FAS) and acetyl-CoA carboxylase 1 (ACC1), ultimately inhibiting lipogenesis and mitigating MAFLD

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Depending on the level of kinetic detail for each step and number of reactions included in the analysis models can go from highly rigorous simulation of a small set of reactions to Boolean or flux models of the whole metabolic network

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