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found SUMO-specific proteases 1 (SENP1) expression was decreased in IH-treated microglia, which reduced the level of Target of Myb 1 (TOM1) and peroxisome proliferator-activated receptor (PPAR) by promoting their SUMOylation, and aggravated neuroinflammation and neuronal apoptosis [97, 98]

This approach allows for an inherent scalability to build models of complex biological phenomena, not afforded by other known methods, since approach obviates the need to create one large monolithic model [1] , which can neither be modularly scaled nor maintained, given the dynamic nature of biological research

PHYSIOLOGICAL RESEARCH, Volume 73, pages 515-527

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