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Aggregation of virions has recently been proposed to contribute to the neutralization of Chikungunya virus 32

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However, the GSH consumed for the initial reactions that are catalyzed by formaldehyde dehydrogenase and glyoxalase 1 will not cause a loss in GSH content as the GSH used as substrate for the initial reactions is regenerated (Figure 2) during the further reactions (Allaman et al

In some embodiments, the otic formulation or composition comprises between about 0.1% to about 30% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof