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For example, the overexpression of SIRT1 can decrease the acetylation level of retinoblastoma protein (Rb) in Pkd1-deficient MEK cells but increase its phosphorylation level, regulating the proliferation signal of renal cystic epithelial cells, and accelerate the growth of cysts in ADPKD patients (Zhou et al., 2013)

Since sleep regulates the brains clearance of metabolic toxins such as tau and A-42 peptides via the glymphatic system, age-related sleep disruption may impair this clearance, thereby exacerbating neuronal pathology through increased ROS production and ultimately triggering neuronal apoptosis (Xie et al., 2013

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