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The lack of efficacy of inhaled GSH in patients with cystic fibrosis could be explained by the high concentrations of the GSH-degrading enzyme -glutamyltransferase present in lung fluids of those patients (116123), and then, the use of precursors of GSH synthesis like NAC and cystine could be more effective in the synthesis of GSH (124)

We prioritized two building blocks for follow-up studies, nipecotamide JS-2 ( 10 ) and cyclopropylmethanamine JS-3 ( 11 ), the latter of which was unintentionally included in the library twice (Fig

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