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This conservation is not surprising as oxidative stress is an inevitable byproduct of aerobic respiration, and GSH is an important antioxidant that mitigates the effects of reactive oxygen species (ROS), such as hydrogen peroxide

10.1016/s0021-9258(18)46874-3 [DOI] [PubMed] [Google Scholar] 135.Thomas DC

In vivo rodent studies have reported hypoglycemia at higher amounts, consistent with the cross-reactivity of IGF-1 at the insulin receptor at supra-physiologic concentrations
