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In the initial inflammatory phase, IL-1 facilitates neutrophil infiltration and macrophage activation, whereas IL-18 supports angiogenesis and epithelial cell proliferation [30]

The peptide does not simply increase nitric oxide levels

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E., AbdelShaheed C., Underwood M., et al., Efficacy, Safety, and Tolerability of Antidepressants for Pain in Adults: Overview of Systematic Reviews, Bmj 380 (2023): e072415
