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iv) Sulfur radical pathways: ROS/RNS generate sulfur radicals (S), leading to disulfide fomation

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This is typically a normal physiological response rather than a direct toxic effect

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Mid-range doses (10-20mg) showed optimal efficacy-to-safety ratio Phase III: ~500 subjects, 24 weeks, failed to reach primary endpoint (statistically significant weight loss vs placebo at 24 weeks)

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Biomarker cut-off values were determined using Youdens index

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