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Jacoby, D
However, under chronic ERS, sustained CHOP activation via ATF4 downregulates anti-apoptotic Bcl-2, upregulates pro-apoptotic Bax, and activates the mitochondrial apoptosis pathway [208]
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These include ALI, ARDS, COPD, asthma and cystic fibrosis (Panati et al., 2020)
