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ZIC-HILIC (2.1 150 mm, Merck Millipore, Burlington, MA, USA) was selected as an analytical column at a temperature of 40 C

doi: 10.1378/chest.13-0584 7 SongZMengYFrickerMLiXTianHTanYet al

As a matter of fact, silymarin, a complex of flavonolignans from the fruit Sylibum marianum , has shown in preclinical test to inhibit cholesterol acyltransferase and HMGCoA reductase activity and improve LDLC uptake by the liver, definitely reducing cholesterol absorption and lipoprotein biosynthesis (Skottov & Krecman, 1998

These issues not only hinder the reproducibility of research but also limit the integration of Chinese medicine into modern medical practices