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doi: 10.1111/tpj.13439

Similarly, treatment with AC markedly halted DU-145 and PC-3 prostate cancer cell proliferation and migration by downregulating the HMGB1/receptor for advanced glycation end products (RAGE) signaling cascade and its downstream transforming growth factor-beta I/II (TGF-I/II)/SMAD family member 2/3 (Smad2/3) pathway

Therefore, patients may require supplements for their whole life to meet the bodys demands for B12

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