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An important future question is in which organismic context FBPs signalling role is most relevant

Insulin-like growth factor-I receptor (IGF-IR) translocates to nucleus and autoregulates IGF-IR gene expression in breast cancer cells

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Some scholars have proposed autoimmune mechanisms, chronic liver diseases, schistosomiasis, and malnutrition as potential cirrhosis causes, yet these remain contentious and necessitate further investigation (Bartolotta et al., 2022)