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In many systems, the affinity ligand is directly attached to the bead

AOD9604 (Advanced Obesity Drug) was developed by Professor Frank Ng at Monash University in Australia in the 1990s, with the intent of finding an anti-obesity drug that had the fat-burning effects of human growth hormone

Karginova O, Weekley CM, Raoul A, Alsayed A, Wu T, Lee SS

Interestingly, excessive ROS production and oxidative stress raises the binding affinity of the spike protein for the human ACE2 receptor (Hati and Bhattacharyya, 2020
