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Description
In HCECs applied with desiccating stress, the CEC ferroptosis was triggered by the aggregation of autophagy impairment-derived sequestosome 1 (SQSTM1), the overexpression of which fostered ferroptotic changes and substantially elevated ACSL4 (124)

Mohrenweiser HW, Novotny JE (1982) ACP1GUA-1a low-activity variant of human erythrocyte acid phosphatase: association with increased glutathione reductase activity

Altern Ther Health Med
But in the cytosol, even during oxidative stress, the ratio of GSH/GSSG remains very high, which makes that exchange reaction unfavorable
