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In contrast to other tissues, the brain exhibits heightened vulnerability to oxidative injury, primarily due to its increased oxygen demand, rich lipid composition, and a relative scarcity of antioxidant enzymes

Liu and colleagues analyzed a cell model of AMD induced by sodium iodate (SI) and reported that SI can consume intracellular GSH, liberate Fe 2+ from liposomes, increase cellular ROS levels, and increase lipid accumulation, leading to ferroptosis in ARPE-19 cells (244)

Available from: www.unodc.org/unodc/en/data-and-analysis/world-drug-report-2022.html Jtc G, sz BE, Tero-Vescan A, Vari CE (2021) Psychoactive drugsfrom chemical structure to oxidative stress related to dopaminergic neurotransmission

105(21): e48747
