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Its importance to human health was first recognized in the early 1960s, when Iranian patients presenting severe anemia, growth retardation, hypogonadism, skin lesions and lethargy were found to be zinc-deficient 1,2

Flagellin and poly(dA: dT) were used as activators for NLRC4 and AIM2, respectively, both of which significantly increased IL-1 release (Supplementary Fig

Also, these findings in healthy adults are unable to be generalized to individuals with acute or chronic health conditions associated with reduced glutathione status, including metabolic syndrome, diabetes, neurodegenerative disease, cancer, HIV/AIDS, pulmonary disease, and/or acute infection