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doi: 10.1097/00001574-200401000-00003
Clinical significance of asparagine synthesis is demonstrated by the fact that the level of expression of the ASNS gene is correlated to metastatic potential in numerous forms of cancer

This comprehensive laboratory surveillance helps rule out organ toxicity or bone marrow suppression that might occur with extended exposure
The low glutamine concentration in human tissues affects the whole body since this amino acid provides nitrogen atoms to the synthesis of purines, pyrimidines, and amino sugars [31]