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Commercial serums offer 12-24 months unopened shelf life with professional preservative systems and 6-12 months post-opening depending on packaging (airless pump best), while DIY serums last only 1-2 weeks refrigerated without professional preservatives
[28]Wu Y, Li X, et al
Earlier initiation may be appropriate when significant comorbidities persist, but timing should be individualized based on surgical procedure type and metabolic status
