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Notably, inflammatory responses play a dual role in tumorigenesis: they can both promote malignant transformation and metastasis and exert an antitumour effect via pyroptosis induction [66]
Second, many clinical trials are of relatively short duration (often 6 months), failing to capture the long-term efficacy and sustainability of interventions on OA progression, a inherently chronic disease
Son Y, Cheong YK, Kim NH, Chung HT, Kang DG, Pae HO (2011) Mitogen-activated protein kinases and reactive oxygen species: how can ROS activate MAPK pathways
doi: 10.1042/bss0610001
