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However, intranasal and oral administration as well as the discovery of antidepressant activity and lower psychotomimetic effect of isomers and metabolites of KET may foster a wider and longer-term clinical use of KET in the future (Zanos et al., 2016)

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The mediation proportions were 26.1% for blood glucose, 11.8% for insulin level, 6.6% for C-reactive protein, 0.6% for cholesterol (not significant), and 0.8% for systolic blood pressure (not significant)