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Limitations of current knowledge: The majority of mechanistic and efficacy data derive from in vitro studies and animal models

[DOI] [PMC free article] [PubMed] [Google Scholar] 43.Sun Q., Zhong W

Membrane lipid peroxidation substantially alters the physical properties of lipid bilayers in terms of disrupted ion gradients, decreased membrane fluidity, slower lateral diffusion, and increased membrane permeability [4548]

This comprehensive search utilized databases such as PubMed, Scopus, and Web of Science, with keywords including ME/CFS, Gut-Brain Axis, Gut Health, Intestinal Dysbiosis, Microbiome Dysbiosis, Pathophysiology, and Therapeutic Approaches. Where possible, insights from clinical trials and observational studies were included to enrich the findings