Glutathione Side Effects: What to Know
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Consistently, PQQ was able to increase GSH expression and Gpx4 activity in cardiomyocytes in vivo and in vitro, in addition to augmenting the FSP1-CoQ10 axis to protect against ferroptosis-associated damage
Oxidative stress then accelerates the aggregation of -synuclein which subsequently binds and sequesters available GSH, creating a destructive feedback loop of protein misfolding and antioxidant loss (Hoepken et al., 2007)
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