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Description
Nmr Biomed

APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice

2013 May-Jun;61(3):226-30

Potential risk factors include genetic predisposition, neurotoxicant exposure (organic solvents, pesticides and heavy metals), chronic nutritional deficiencies, metabolic disorders, immune dysregulation, viral infections and neuroinflammation (Newell et al., 2022
