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Further, thermolability studies showed that MMACHC protein is strongly stabilised by cobalamin binding, whereas mutant protein was much less stabilised and only minimally or not at all with CNCbl (Ref

Mohan S, Mohan L, Sangal R, Singh N
Furthermore, tamoxifen treatment also demonstrated some clinical activity in patients with metastatic melanomas 31 and glioblastomas 32
Apart from nicotinamide metabolism adaption during disease relapse or refractory stages, earlier studies have shown the leukemic blasts and LSCs have evolved a complex adaptation of metabolic flexibility through cell intrinsic, partly due to the selection pressure from the chemotherapy and through various microenvironmental mechanisms
