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The central part is focused on post-translational modifications of lysine in proteins, primarily desmosine formation in elastin, hydroxylation in collagen, covalent bonds with glutamine, methylation, ubiquitination, sumoylation, neddylation, acylation, lactylation, carbamylation, and glycation

It can therefore be concluded that ToxCast PPAR and RXR assays and some of the computational tool predictions available from the US EPA Chemical Dashboard, are suitable for high throughput screening (HTS) in the identification of potential hazards and prioritisation of chemicals from large chemical libraries that could not otherwise be screened in lower-throughput model systems

doi: 10.3390/molecules201018886 117 TanD

Virgili A, Rosaria Zampino M, Bacilieri S, Bettoli V, Chiarelli M