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NRF2 activation can also result in increased xCT accumulation, which eventually results in high GSH dependency of the affected cells
Cancer Cell 41 , 12421260.e1246 (2023)
The activation of these kinases results in the phosphorylation of IRS1 on serine 307 resulting in inhibition of the insulin-stimulated tyrosine phosphorylation of IRS1 leading to inhibition of insulin signaling
