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According to these evidences, the activation of NF-kB in pinealocytes through immune cells at AD brain results in the activation of Aanat gene, leading to the production of melatonin (Fig

doi: 10.1038/cr.2010.178 [DOI] [PMC free article] [PubMed] [Google Scholar] 75.Xiao R, Huang X, Gao S, Duan J, Zhang Y, Zhang M

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A treatment must be validated by rigorous studies demonstrating its superiority over placebo to be considered effective
