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Glutathione is preferentially produced in the liver, but is found in all cells of the organism, in particularly high quantities (apart from the liver) in red blood cells and the cells of the immune system

Reducing glutathione production in lymphoma cells, either through pharmacological inhibition of glutamate cysteine ligase (GCL), the enzyme catalyzing the rate-limiting step in glutathione biosynthesis, or via knockdown of GCLC, the GCL catalytic subunit, sharply decreased cell growth in 3D gels and xenografts

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