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Within the brain, DSIP is particularly abundant in the hypothalamus, hippocampus, and limbic regions, where it interacts with multiple peptide and non-peptide mediators, including corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), and melanin-concentrating hormone (MCH)

Herein, we review the potential mechanism by which NNMT promotes cancer progression and resistance
