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The level of H3K27me3 serves as an indirect marker of CD38/NAD/SIRT1/EZH2 axis activity, in which increased CD38 expression leads to NAD + reduction, causing SIRT1 inhibition followed by increased EZH2 acetylation and trimethylation of Lys-27 in histone 3 (H3K27me3) (30)

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To stratify the risk of CMV infection after kidney transplantation, clinicians evaluate the anti-CMV IgG serology match of the donor (D) and recipient (R) (4), where + indicates that the individual is anti-CMV IgG positive and indicates that the individual is anti-CMV IgG negative