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2.1.2 Molecular and cellular mechanisms underlying the pathogenesis of AD Amyloid plaques arise from the aggregation of A peptides, particularly A4 2 , which is harmful due to its tendency to form plaques and resist dissolving (Jarrett et al., 1993)

In addition, inherited conditions may also cause dementia alongside other features include: Alexander disease, Canavan disease, cerebrotendinous xanthomatosis, fragile X-associated tremor/ataxia syndrome, glutaric aciduria type 1 , Krabbe's disease, maple syrup urine disease, Niemann Pick disease type C, ufs' disease, neuroacanthocytosis, organic acidemias, Pelizaeus-Merzbacher disease, urea cycle disorders, Sanfilippo syndrome type B, and spinocerebellar ataxia type 2

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In addition, other strategies were also assayed because the intestinal GSH depletion could be generated not only by drugs but also by pathological conditions such as cholestasis and metabolic syndrome[58,63]