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A growing body of research literature has examined GHK-Cu's effects on hair follicle biology, building on its established role in extracellular matrix remodeling and its upregulation of genes associated with extracellular matrix remodeling, such as decorin and TGF- receptors, alongside downregulation of inflammatory cytokines including IL-6 and TNF- pathways relevant to follicle miniaturization research models

Preclinical models report tendon, ligament, muscle, and gut healing benefits, but human evidence remains limited to a handful of small open-label pilot studies

Preliminary studies suggest it is well-tolerated, but long-term safety and potential neurologic impacts need further investigation

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