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The nasal-brain drug delivery route: mechanisms and applications to central nervous system diseases

Vascularogenesis is a complex biological process involving interactions between vascular-forming cells and the extracellular environment, and miRNAs are key regulators of endothelial cell function, particularly in vascularogenesis ( in vitro , conditioned medium from mesen-chymal stem cells (MSCs) has angiogenic potential and found that EVs derived from MSCs can carry various miRNAs associated with angiogenesis and transfer these miRNAs to endothelial cells, thereby promoting angiogenesis (Wang W

Stefanelli, T., Malesci, A., Repici, A., Vetrano, S