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The above observation suggests that a hominid species or a modified mouse carrying the human Met gene seems essential, to examine the human therapeutic efficacy of these dimeric macrocycles in future animal experiments

Additionally, at concentrations of 840 M, 13-HOA significantly suppressed TPA-induced anchorage-independent growth in JB6 epidermal cells by 70100%, and at 40 M, it inhibited AP-1 activity

It also affects translation of HIF-1 and HIF-2, causing inhibition of the HIF pathway 31

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