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Description
Mitochondria morphological changes are associated with dysfunction and altered energy metabolism, whereby adenosine triphosphate (ATP) production is insufficient to maintain the Na+/K+-ATPase neuronal activity, which leads to massive calcium (Ca +2 ) influx followed by glutamate toxicity [24]
Schmitt J
doi: 10.3390/molecules28010240 72
For instance, the loss of proteolytic activity impairs lysosome localization and motility, leading to autophagosome accumulation
