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Future research must address challenges in identifying reliable biomarkers, understanding subphenotype-specific mechanisms, and integrating ferroptosis inhibitors into existing therapeutic frameworks

For instance, lentiviral vectors engineered viruses used to stably deliver genes into target cells for gene therapy have been used to target the dynein axonemal intermediate chain 1 gene in airway epithelial cells, restoring ciliary beating for primary ciliary dyskinesia treatment

In p43-overexpressing mice, mitochondrial mass initially increases, but mitochondrial DNA content declines over time, impairing mitochondrial function

It is also recommended that subcutaneous injection sites be periodically rotated