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glutathione peroxidase liver detox The role of peroxidase-1 in health and disease Therapeutic strategies for liver diseases
Description
Coupled steady-state kinetic measurements with GSSR and GSH revealed that both half-reactions usually occur with second order rate constants around 10 5 to 10 6 M 1 s 1 with the reductive half-reaction being slower for wild-type glutaredoxins 11,14,15,17,19
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These findings suggest that the AMG-mediated decrease in GPx-1-specific activity was caused by loss of a key amino acid at the enzymatic active site
doi: 10.1134/S1819712421020057 37
