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In this setting, TGF1 is probably the primary pro-fibrogenic factor in the formation of fibrotic plaques ( in vitro ( On the other hand, it is reported that TGF1 is a possible driver of Rho-associated coiled-coil protein kinase (ROCK) ( Fibrotic conditions often involve an imbalance between deposition and degradation of ECM in the proliferation and remodeling phase
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