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A modest upregulation of the ERK pathway was more apparent in serum-starved, low-nutrient conditions (1% FCS, 2 mM Glucose) for the G12V and G12D cell lines (Figure S1D), suggesting that these mutants are more capable of sustaining this signalling cascade than the others in limited nutrient and growth factor conditions

Liver disease and arthritis tend to occur concomitantly

We found ABC-transporters and P-type ATPases to be commonly associated with Cd and Hg tolerance, which is supported by previous functional studies among members of these gene families playing large roles in heavy metal transport across membranes and isolation in vacuoles

This concept was first consolidated by Michael Brownlee and colleagues, who between 1995 and 2005 proposed an integrated mechanistic model, describing mitochondrial superoxide overproduction as the central driver of hyperglycemia-induced vascular injury [56, 79, 229, 230]