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Glutathione binds these harmful substances during phase II detoxification, converting them into water-soluble forms that the body can safely excrete

[186] utilized computational methods to understand immune responses in COVID-19 patients (who presented obesity (37%) and T2DM (19%)) during the week following the initial diagnosis, where the up-regulated dataset which contains MT2A and MT1-E proteins were positively correlated with M2 in CD8 + T cells and these proteins were involved in the cellular response to Zn ion

(Academic Press, 1972)

It should be noted that some of the sponsors to date have partnerships with large pharmaceutical companies (e.g., Pfizer, Sanofi, Novartis or Merck), which highlights the significant funding attracted by this cutting-edge drug strategy, indicating that cereblon-based PROTACs have a huge promising potential