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It is known that insulin is involved in neuronal survival, synaptic plasticity, memory, and cognitive function in the central nervous system (CNS), and existing hypotheses suggest that similar to diabetic neuropathy, impaired insulin signalling pathways due to elevated blood glucose and lipids may be the main metabolic mechanism that induces the occurrence of diabetic cognitive dysfunction (6)

These two enzymatic reactions together provide the necessary lipid substrates for ferroptosis ( 2

Since beta carotene is an important antioxidant, and it can enhance its activity with fellow antioxidants, it is important to study the different interaction between beta carotene and ROS within the various organ systems and how that correlates to long-term spaceflight

This drug and dosing regimen has demonstrated efficacy in non-human primates after high-dose radiation therapy (Farese 2012) and, as of this writing, Extimia is being evaluated in an open-label randomized phase II clinical study (BCD-017-2), which is expected to conclude in 2013 (ClinicalTrials.gov 2012a)